Vesicle Trafficking in Cancer

Vesicle Trafficking in Cancer

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Endocytosis and vesicular trafficking determine the landscape of the cella€™s exterior, namely the density of surface molecules, such as receptors for growth factors and cytokines, adhesion molecules like integrins and cadherins, and a plethora of nutrient carriers. Hence, endocytosis is involved in signal transduction, cell adhesion and migration, as well as metabolism. To exploit these fundamental processes, malignancies subtly and multiply manipulate the endocytosis and the subsequent trafficking of protein cargoes. This is achieved by simultaneously altering the cytoskeleton, vesicle budding, cargo sorting and intracellular degradation. By highlighting the underlying molecular processes and concentrating on specific examples, this book reviews the recent emergence of derailed endocytosis and vesicular trafficking as a landmark of cancer. In-depth understanding of this common feature of tumors might lead the way to drug-induced strategies, able to rectify intracellular trafficking in cancer.... Hartley JA, Hochhauser D (2011) EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing ... Di Vizio D, Lee J S, Jhaveri R, Rubin MA et al (2007) The phosphoinositide kinase PIKfyve mediates epidermal growthanbsp;...

Title:Vesicle Trafficking in Cancer
Author: Yosef Yarden, Gabi Tarcic
Publisher:Springer Science & Business Media - 2013-04-02

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